Table 2.
Frequency of organ system damage as determined by VDI and CDA and the correlation between the total score for each organ system between the two disease damage tools in patients with vasculitis
| Score | Frequency of organ damage as determined by VDI, n (%) | Median VDI score (range) for each organ | Frequency of organ damage as determined by CDA, n (%) | Median CDA score (range) for each organ | Spearman’s rank correlation coefficient for total score in each organ system (95% CI) |
|---|---|---|---|---|---|
| Total score | 213 (76.6) | 2 (0–12) | 212 (76.3) | 3 (0–26) | 0.90 (0.87 to 0.92) |
| Musculoskeletal | 46 (16.6) | 0 (0–3) | 45 (16.2) | 0 (0–4) | 0.86 (0.83 to 0.89) |
| Skin/mucous membranes* | 20 (7.2) | 0 (0–3) | 76 (27.3) | 0 (0–4) | 0.47 (0.38 to 0.56) |
| Ocular | 46 (16.6) | 0 (0–3) | 52 (18.7) | 0 (0–6) | 0.94 (0.93 to 0.96) |
| ENT† | 110 (39.6) | 0 (0–5) | 108 (38.9) | 0 (0–13) | 0.89 (0.86 to 0.91) |
| Pulmonary | 42 (15.1) | 0 (0–3) | 43 (15.5) | 0 (0–3) | 0.94 (0.92 to 0.95) |
| Cardiovascular | 50 (18.0) | 0 (0–3) | 67 (24.1) | 0 (0–5) | 0.77 (0.72 to 0.82) |
| Peripheral vascular disease | 13 (4.7) | 0 (0–3) | 20 (7.2) | 0 (0–4) | 0.81 (0.77 to 0.85) |
| Gastrointestinal | 1 (0.4) | 0 (0–1) | 2 (0.7) | 0 (0–1) | 0.71 (0.64 to 0.76) |
| Renal | 61 (21.9) | 0 (0–3) | 67 (24.1) | 0 (0–7) | 0.89 (0.86 to 0.91) |
| Neuropsychiatric‡ | 74 (26.6) | 0 (0–2) | 92 (33.1) | 0 (0–4) | 0.75 (0.70 to 0.80) |
| Endocrine | NA | NA | 30 (10.8) | 0 (0–2) | |
| Haematology/oncology§ | NA | NA | 4 (1.4) | 0 (0–1) | |
| Other¶ | 59 (21.2) | 0 (0–2) | 69 (24.8) | 0 (0–2) |
The p value for all Spearman’s correlations is less than 0.001.
The main reason for discrepancy is the inclusion of skin bruising and scaring on the CDA; items not present on the VDI. When these two items were removed from the analysis the Spearman’s ρ was 0.70 (95% CI 0.64 to 0.76).
ENT is composed of four separate categories on the CDA: ears, nose, sinuses and subglottic stenosis.
More than 80% of this organ system involvement was accounted for by peripheral neuropathy.
Haematology and oncology items are captured under ‘other’ in the VDI.
Weight gain >10 lbs/4.4 kg was the main item captured under ‘other’ on the CDA (14.8%). Weight gain is not present as an individual item on the VDI. CDA, Combined Damage Assessment Index; ENT, ear, nose and throat; VDI, Vasculitis Damage Index.