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TAM-metabolic pathways and selected CYP450 enzymes.
Notes: TAM was metabolized by CYP450 enzyme to its active metabolites: END and 4OHT. END was created via NDMT and 4OHT.
Abbreviations: TAM, tamoxifen; CYP450, cytochrome P450; END, endoxifen; 4OHT, 4-hydroxy-tamoxifen; NDMT, N-desmethyl tamoxifen.
