Table 1.
Prevalence of CYP2D6 and CYP3A5 polymorphisms in Caucasians, Asians, and Thais
| Allele/genotype | Prevalence (%)
|
||
|---|---|---|---|
| Caucasians | Asians | Thais | |
| CYP2D6 | |||
| *1 | 76.724 | 49.0–100.014 | 35.08–47.016 |
| *2 | 0.024 | 19.014 | 9.68 |
| *4 | 11.724 | <1.014 | 0.98 |
| *10 | 0.424 | 51.014 | 53.016 |
| *1/*1 | 63.924 | 30.2–100.014 | 15.78–27.116 |
| *1/*2 | 0.024 | 26.614 | 3.58 |
| *2/*2 | 0.024 | 7.214 | 3.58 |
| *1/*4 | 15.024 | 0.714 | 0.08 |
| *4/*4 | 1.524 | 0.014 | 0.08 |
| *2/*4 | 0.024 | 0.014 | 1.88 |
| *1/*10 | 0.024 | 38.914 | 39.016 |
| *2/*10 | 0.024 | 0.014 | 7.08 |
| *4/*10 | 0.7524 | 0.014 | 0.08 |
| *10/*10 | 0.024 | 30.914 | 33.916 |
| CYP3A5 | |||
| *1 | 2.224 | 30.014 | 80.09 |
| *3 | 97.824 | 70.014 | 20.09 |
| *1/*1 | 0.024 | 8.514 | 63.09 |
| *1/*3 | 4.424 | 43.614 | 33.09 |
| *3/*3 | 95.624 | 47.914 | 4.09 |
Note: Adapted from Copyright © 2013. PLoS One. Fernández-Santander A, Gaibar M, Novillo A, et al. Relationship between genotypes SULT1A2 and CYP2D6 and tamoxifen metabolism in breast cancer patients. 2013;8(7):e70183.24 © 2011 The Authors. British Journal of Clinical Pharmacology © 2011. The British Pharmacological Society. Lim JS, Chen XA, Singh O, et al. Impact of CYP2D6, CYP3A5, CYP2C9 and CYP2C19 polymorphisms on tamoxifen pharmacokinetics in Asian breast cancer patients. 2011;71(5):737–750.14