Table 7.
Prevalence of CYP2D6 and CYP3A5 polymorphisms in Caucasians and Thais
| Allele/genotype (phenotype) | Prevalence (%)
|
|
|---|---|---|
| Caucasians24 | Thais (this study) | |
| CYP2D6 | ||
| *1 (wild type) | 76.7 | 72.9 |
| *2 (wild type) | 0.0 | 3.2 |
| *4 (null allele) | 11.7 | 1.1 |
| *10 (reduced allele) | 0.4 | 22.8 |
| *1/*1 (EM) | 63.9 | 9.7 |
| *1/*2 (EM) | 0.0 | 2.2 |
| *2/*2 (EM) | 0.0 | 3.7 |
| *1/*4 (EM) | 15.0 | 0.0 |
| *4/*4 (PM) | 1.5 | 1.5 |
| *2/*4 (EM) | 0.0 | 0.0 |
| *1/*10 (EM) | 0.0 | 15.7 |
| *2/*10 (EM) | 0.0 | 9.7 |
| *4/*10 (IM) | 0.75 | 3.7 |
| *10/*10 (IM) | 0.0 | 53.7 |
| CYP3A5 | ||
| *1 (wild type) | 2.2 | 37.3 |
| *3 (null allele) | 97.8 | 62.7 |
| *1/*1 (EM) | 0.0 | 13.4 |
| *1/*3 (EM) | 4.4 | 47.8 |
| *3/*3 (PM) | 95.6 | 38.8 |
Note: Adapted from Copyright © 2013. PLoS One. Fernández-Santander A, Gaibar M, Novillo A, et al. Relationship between genotypes SULT1A2 and CYP2D6 and tamoxifen metabolism in breast cancer patients. 2013;8(7):e70183.24 The phenotype classification in this table was defined by the authors of this article.
Abbreviations: EM, extensive metabolizer; IM, intermediate metabolizer; PM, poor metabolizer.