Time course of effects of administration of tryptophan on liver tryptophan and kynurenine metabolite concentrations.
Notes: Tryptophan (50 mg/kg body weight) was administered intraperitoneally at zero time, and liver tryptophan and kynurenine metabolite concentrations were determined as described in the Materials and Methods section at the time intervals indicated. Values are mean ± SEM for five rats. The significance of the differences from the control zero-time value is indicated by an asterisk, with levels of significance (P) of 0.046–0.001.
Abbreviations: Trp, tryptophan; K, kynurenine; 3-HK, 3-hydroxykynurenine; 3-HAA, 3-hydroxyanthranilic acid; KA, kynurenic acid; XA, xanthurenic acid; AA, anthranilic acid.