Table 1.
Effects of acute administration of various doses of KA on concentrations of some kynurenine metabolites in rat liver and serum.
| DOSE OF KA (mg/kg) | 3-HK | 3-HAA | KA | AA | |
|---|---|---|---|---|---|
| 0 | Liver | 2.86 ± 0.68 | 0.10 ± 0.01 | 0.07 ± 0.02 | 0.16 ±0.06 |
| Serum | 3.79 ± 0.32 | 0.95 ± 0.12 | 0.85 ± 0.18 | UD | |
| 1 | Liver | 3.47 ± 0.65 | 0.18 ± 0.06 | 28.1 ± 1.2* | 0.53 ±0.21 |
| Serum | 3.46 ± 0.27 | 0.75 ± 0.08 | 3.20 ± 0.59* | (0.05, 0.41) | |
| 2.5 | Liver | 18.6 ± 1.0* | 1.13 ± 0.32* | 30.6 ± 0.8* | 0.27 ± 0.14 |
| Serum | 4.87 ± 0.32* | 0.61 ± 0.09 | 3.28 ± 0.09* | UD | |
| 5 | Liver | 11.6 ± 3.9* | 1.67 ± 0.74 | 35.1 ± 5.2* | 0.89 ± 0.54 |
| Serum | 3.55 ± 0.44 | 0.81 ± 0.18 | 4.01 ± 0.45* | (0.10, 0.01) | |
| 7.5 | Liver | 16.0 ± 1.0* | 1.62 ± 0.74 | 37.4 ± 18.8* | 1.01 ± 0.35* |
| Serum | 4.59 ± 0.47 | 0.61 ± 0.13 | 11.2 ± 0.2* | (0.24) | |
| 10 | Liver | 18.8 ± 0.1* | 0.84 ± 0.25* | 54.5 ± 9.6* | 0.39 ± 0.11 |
| Serum | 4.90 ± 0.43 | 0.52 ± 0.06 | 26.4 ± 1.4* | (0.01, 0.19) |
Notes: Rats were given an intraperitoneal injection of various doses of KA or physiological saline and were killed one hour later. Values are mean ± SEM for each group of five rats, except for individual values in parentheses. The significance of the differences from the zero dose control group is indicated by an asterisk (*) (P = 0.042–0.001 by t-test).