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. Author manuscript; available in PMC: 2017 Aug 1.
Published in final edited form as: Medchemcomm. 2016 Jun 20;7(8):1672–1680. doi: 10.1039/C6MD00277C

Table 2.

IC50 (µM) of 7a–r for a selected panel of PTPs.

7a–c 7d 7e–f 7g 7h 7i 7j 7k 7l 7m 7n 7o 7p 7q 7r
mPTPB - - - 18.1
± 9.5		 5.1
± 0.4		 9.4
± 0.2		 14.4
± 1.9		 7.3
± 0.5		 4.8
± 0.1		 - 4.7
± 0.2		 - 2.9
± 0.1		 2.6
± 0.1		 2.3
± 0.1
SHP2 - 9.0
± 2.2		 - - 6.7
± 1.2		 6.9
± 1.4		 19.0
± 25.6		 8.5
± 1.4		 3.5
± 0.5		 - - 19.5
± 47.8		 3.2
± 0.3		 12.8
± 3.6		 20.3
± 18.6
PTP1B - 14.7
± 3.0		 - - 12.6
± 4.8		 13.8
± 2.0		 17.2
± 8.9		 - - - - 6.6
± 1.3		 - -
CD45 - 7.6
± 0.8		 - - 5.2
± 0.6		 6.6
± 0.6		 - 7.8
± 0.5		 3.4
± 0.2		 - 29.1
± 38.2		 14.9
± 7.2		 2.8
± 0.2		 10.9
± 1.4		 16.1
± 5.0
LYP - 10.1
± 0.8		 - - 6.9
± 1.1		 7.5
± 0.8		 - 8.8
± 1.1		 - - - 20.6
± 35.9		 3.4
± 0.3		 14.3
± 3.1		 15.4
± 3.1
FAP-1 - 7.4
± 0.8		 - - 4.3
± 1.8		 5.6
± 0.7		 - 6.5
± 0.7		 2.8
± 0.3		 - - 12.4
± 8.3		 2.2
± 0.3		 9.9
± 1.5		 14.9
± 5.2

A “-“ indicates IC50 >> 20µM.