Table 2.
Fold change of the gene expression of macrophages cocultured with OCUM‐12 gastric cancer cells compared to normal macrophages
| Gene groups | Fold change |
|---|---|
| Extracellular matrix molecules | |
| MMP1 | 6.34 |
| MMP7 | 6.99 |
| MMP8 | 20.46 |
| MMP10 | 2.59 |
| MMP11 | 2.96 |
| MMP12 | 44.46 |
| MMP14 | 4.97 |
| TIMP metallopeptidase inhibitor 1 | 8.60 |
| Laminin, α3 | 6.25 |
| Laminin, β1 | 2.94 |
| Versican | 143.45 |
| Cell adhesion molecules | |
| CD44 | 3.69 |
| Hyaluronan synthase 1 | 53.24 |
| Integrin, α1 | 11.83 |
| Integrin, α7 | 8.31 |
| Thrombospondin 1 | 6.94 |
| Cytokines | |
| IL‐1β | 114.31 |
| IL‐6 | 2026.25 |
| IL‐8 | 117.68 |
| IL‐10 | 1.43 |
| IL‐12 | 0.54 |
| IL‐18 | 0.15 |
| TGF‐β | 0.43 |
| Growth factors and receptors | |
| VEGF‐A | 4.98 |
| VEGF‐C | 6.45 |
| VEGFR‐2 | 0.06 |
| VEGFR‐3 | 0.22 |
| Chemokines and receptor | |
| CXCL1 | 143.84 |
| CXCL2 | 6.01 |
| CXCL6 | 1611.56 |
| CXCR2 | 0.07 |
CXCL, chemokine (C‐X‐C motif) ligand; CXCR, chemokine (C‐X‐C motif) receptor; IL, interleukin; TGF‐β IL, transforming growth factor‐β interleukin; TGF‐ receptorg; TIMP, tissue inhibitor of metalloproteases; VEGF, vascular endothelial growth factor; VEGFR, vascular endothelial growth factor receptor.