Figure 2.

Development of adult T‐cell leukemia‐like disease in NSG mice. (a) Kaplan–Meier analysis of the probability of disease‐free survival. Ink4a/Arf‐null or ‐proficient T cells were transduced with the indicated genes and transplanted into irradiated NSG mice. The difference in probabilities was evaluated statistically using the log–rank test. N.S., not significant. (b) Flow cytometric analysis of cells before and after transplantation for the expression of Akt, BCLxL, and HBZ (represented by GFP, human [h]CD4, and hCD8, respectively) and for the expression of mouse CD4 and mouse CD8. PB, peripheral blood of mouse #4; Thy, thymus. (c) “Flower cell”‐like T cells in the thymus and peripheral blood. (d) Histology of the indicated organs by HE staining.