Table 1.
Features of NSG mice transplanted with HBZ/Akt/BCLxL triply transduced Ink4a/Arf‐null T cells
| Mouse ID | Dpt | HBZ/Akt/BCLxL triple‐positive cells (%) | CD4+CD8− †, % | CD4−CD8+ †, % | CD4+CD8+ †, % | Spl. weight, mg | Flower cell‡ | Observation | |||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BM | Thy | Spl | PB | ||||||||
| #1 | 104 | n.d. | n.d. | n.d. | n.d. | n.d. | n.d. | n.d. | n.d. | N.E. | Found dead |
| #2 | 104 | n.d. | n.d. | n.d. | n.d. | n.d. | n.d. | n.d. | n.d. | N.E. | Found dead |
| #3 | 49 | n.d. | 97.5 | 83.0 | 40.3 | 10.8 | <0.1 | 89.2 | 216 | + | Submandibular tumor§ |
| #4 | 75 | 0.3 | 99.0 | N.E. | 23.0 | 80.8 | <0.1 | <0.1 | N.E. | + | No discernible spleen |
| #5 | 41 | 0.9 | <0.1 | <0.1 | 26.4 | 8.3 | 20.5 | 60.2 | n.d. | + | |
| #6 | 21 | n.d. | n.d. | n.d. | n.d. | n.d. | n.d. | n.d. | n.d. | N.E. | Found dead |
| #7 | 49 | 99.9 | 98.6 | 61.0 | 92.4 | <0.1 | 83.4 | <0.1 | 229 | − | |
†Percentages of CD4/CD8 represent those of cells in submandibular tumor (#3), thymus (Thy) (#4), peripheral blood (PB) (#5), and bone marrow (BM) (#7). ‡Flower cell‐like cells were present (+) in submandibular tumor (#3), Thy and PB (#4), and PB (#5). §Percentage of HBZ/Akt/BCLxL triple‐positive cells in the tumor was 98.5%. −, Not present; Dpt, days post‐transplantation; n.d., not done; N.E., not evaluable; Spl, spleen.