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. 2016 Aug 12;11(8):e0161067. doi: 10.1371/journal.pone.0161067

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© 2016 Togo et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 1 — Histological analysis (H&E staining) of frontal sections of molar teeth from E15 (A-D) and P0 (E-H) mice. At E15, the molars of the Usag-1^+/+/Runx2^-/- mice (B) were at the bud stage while the molars of all the other mice were at the late cap stage. The Usag-1^+/+/Runx2^-/- mouse molars each exhibited a distinct lingual bud (B, arrow). At P0, morphological examinations indicated that molar tooth development had arrested in the Usag-1^+/+/Runx2^-/- mice (F) compared with the other transgenic mouse lines (G & H), which displayed similar molar tooth morphology to the wild-type mice (E). Lin: Lingual side.