TABLE 3.
B4GALT2 genotype and on-treatment platelet reactivity
| Cohort | B4GALT2 Genotype | PRU | P-Value | RPA | P-Value | |
|---|---|---|---|---|---|---|
| Discovery Cohort n=636 | rs1061781 (c.909C>T) | |||||
| Non-carriers (n=510) | 172.1±87.1 | 0.0077 * | 33.1±23.4 | 0.0008 * | ||
| Carriers (n=125) | 148.7±90.0 | 25.2±22.6 | ||||
| rs1859728 (c.366G>C) | ||||||
| Non-carriers (n=547) | 170.6±86.6 | 0.0211 * | 32.6±23.3 | 0.0046 * | ||
| Carriers (n=86) | 147.0±96.1 | 24.9±23.0 | ||||
| rs1061781 (c.909C>T) | ||||||
| C/C (n=510) | 172.1±87.1 | 0.034 † | 33.1±23.4 | 0.0028 † | ||
| C/T (n=120) | 148.2±90.7 | 25.2±22.5 | ||||
| T/T (n=5) | 159.4±79.3 | 25.2±26.1 | ||||
| rs1859728 (c.366G>C) | ||||||
| G/G (n=547) | 170.6±86.6 | 0.0352 † | 32.6±23.3 | 0.0134 † | ||
| G/C (n=83) | 148.3±97.1 | 25.2±23.2 | ||||
| C/C (n=3) | 110.4±57.2 | 17.6±14.7 | ||||
| Replication Cohort ‡ n=160 | rs1061781 (c.909C>T) | |||||
| Non-carriers (n=140) | 233.5±17.2 | 0.0001 * | ND | ND | ||
| Carriers (n=20) | 142.6±42.2 | ND | ||||
| rs1859728 (c.366G>C) | ||||||
| Non-carriers (n=147) | 225.7±16.9 | 0.0740 * | ND | ND | ||
| Carriers (n=13) | 181.4±76.3 | ND | ||||
ND: Not determined; PRU: P2Y12 reaction units; RPA: residual platelet aggregation.
*
P-value using t-test.
†
P-value using Kruskal-Wallis one-way analysis of variance.
‡
Platelet reactivity in the replication cohort was only measured by the VerifyNow™ P2Y12 assay, and genotype association with PRU was not performed due to the limited number of homozygous variant carriers.