Figure 1.

Schematic of Neutrophil Uropod. (A) Side and top view of a neutrophil in a zebrafish larva shows polarized morphology of a migrating neutrophil. (B) Organization and makeup of the uropod. Molecular components of the uropod including Rho, ROCK, and myosin II maintain contractility and generate force at the rear. Other signaling proteins, such as adhesion molecules, flotillins, ERM proteins, and microtubules, are localized to the uropod and contribute to neutrophil polarization and migration. The neutrophil uropod functions by providing high contractility and breaking of adhesions at the rear.