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. 2016 Jun 2;39:873–881. doi: 10.1007/s40264-016-0433-x

Table 3.

Performance of signal detection algorithms across age strata

Age groups and signal detection algorithms Size of the age stratum (number of reports) AUC
Neonates 5091
 Number of reports 0.625
 EBGM 0.600
 PRR 0.65
Infants 12,566
 Number of reports 0.667
 EBGM 0.548
 PRR 0.554
Children 49,982
 Number of reports 0.654
 EBGM 0.698
 PRR 0.649
Adolescents 48,035
 Number of reports 0.698
 EBGM 0.771
 PRR 0.718
Entire pediatric population
 Number of reports 115,674 0.634
 EBGM 0.746
 PRR 0.733

AUC area under the curve, EBGM empirical Bayes geometric mean, PRR proportional reporting ratio