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Co-incubation with etoposide and valspodar (PSC833), a selective inhibitor of PGP efflux activity did not see a loss in oocyte vitality. The cytotoxicity of etoposide and PSC833 were evaluated using as a standard far red detectable live/dead vitality reagent. Analysis confirmed that in no instance was there an associated decrease in oocyte vitality following treatment exposure n=3.
