Figure 4.

Osx⁺ Cell Deletion Leads to Blockade of pro-B to pre-B Transition and Impairs Adaptive Immunity

(A) Analysis of intermediate stages of B cell maturation in the OsxCre;iDTR mutants compared with control littermates.

(B and C) Animals were challenged with NP-Ficoll to produce immunoglobulins in a T cell-independent manner. Production of IgG (B) and IgM (C) were assessed over 28 days.

Three independent experiments; n = 12–16/group. ^∗p < 0.05, ^∗∗p < 0.01, ^∗∗∗p < 0.001. Error bars represent ± SEM.