Osx+ Cell Deletion Leads to Blockade of pro-B to pre-B Transition and Impairs Adaptive Immunity
(A) Analysis of intermediate stages of B cell maturation in the OsxCre;iDTR mutants compared with control littermates.
(B and C) Animals were challenged with NP-Ficoll to produce immunoglobulins in a T cell-independent manner. Production of IgG (B) and IgM (C) were assessed over 28 days.
Three independent experiments; n = 12–16/group. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001. Error bars represent ± SEM.