Table 2.

Pearson correlations for the combined in vitro potency estimates of cell lines exposed to particles

J774A.1 vs. A549 cells	Cytotoxicity		Cytokine induction
	βV	βR	βI-V	βI-V LO	βI-V HI
R	0.741	0.729	0.020	−0.089	−0.108
p (2-tailed)	0.035	0.040	0.963	0.835	0.800

Consensus cytotoxic potency β_V is calculated from in vitro assays conducted in individual cell lines

Biological reactivity of the particles β_R represent absolute values of cytotoxic potency

Consensus inflammatory potency β_I-V represents the average unbiased particle potency response for inducing a cytokine response, where LO and HI are the lower and upper estimates of the index based on the pro- and anti-inflammatory effects of some cytokines

Numbers in bold represent statistically significant correlations (p ≤ 0.05)