Table 4.

Multivariate analysis of factors predicting survival in the entire patient population and in the diabetic patient population

Variable	All patients
	HR	95 % CI	P
Gender	1.39	1.13–1.72	0.002
Smoking History	1.18	0.95–1.44	0.132
Histology	0.92	0.75–1.12	0.421
Clinical Stage IIIB-IV	2.03	1.33–3.08	0.001
ECOG Performance Status	1.26	1.10–1.43	0.001
Metformin use	0.53	0.37–0.75	<0.0001
Glycemic control	0.49	0.39–0.63	<0.0001
	Diabetic patient population
	HR	95 % CI	P
Gender	1.36	0.80–2.33	0.256
Smoking History	1.35	0.79–2.31	0.277
Clinical Stage IIIB-IV	3.01	0.92–9.84	0.068
Metformin use	0.57	0.36–0.90	0.017
Proper glycemic control	0.40	0.22–0.71	0.002