Table 2.
Description of the antibiotic prescriptions in the two periods of the study. n(%)
| Period 1 (10 centres) | Period 1 (3 centres) | Period 2 (3 centres) | p* | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Total | Compliant | Non-compliant | Total | Compliant | Non-compliant | Total | Compliant | Non-compliant | ||
| N = 3034 | N = 1562 | N = 1472 | N = 1292 | N = 672 | N = 620 | N = 293 | N = 237 | N = 56 | ||
| Mode | ||||||||||
| None | 126 (4.1) | 0 | 126 (8.6) | 9 (0.7) | 0 | 9 (1.5) | 1 (0.3) | 0 | 1 (1.8) | 0.5 |
| Oral | 2292 (75.5) | 1558 (99.7) | 734 (49.8) | 1035 (80.6) | 669 (99.7) | 366 (59.0) | 257 (87.7) | 221 (92.9) | 36 (27.3) | 0.002 |
| IV | 616 (20.3) | 4 (0.3) | 612 (41.6) | 248 (19.4) | 3 (0.3) | 245 (39.5) | 35 (12) | 16 (7.1) | 19 (70.9) | 0.003 |
| Generic name | ||||||||||
| Amoxicillin | 1764 (58.1) | 1526 (97.7) | 238 (17.6) | 700 (54.2) | 655 (97.5) | 45 (7.3) | 208 (71) | 203 (87.1) | 5 (4.1) | <0.001 |
| Amoxicillin + macrolide | 98 (3.2) | 3 (0.3) | 95 (7.1) | 49 (3.8) | 1 (0.2) | 48 (7.7) | 13 (4.4) | 0 | 13 (20.4) | 0.6 |
| 3rd G cephalosporin | 277 (9.1) | 1 (0.1) | 276 (19.5) | 157 (12.2) | 0 | 157 (25.3) | 15 (5.1) | 6 (2.6) | 9 (18.3) | <0.001 |
| Macrolide | 93 (3.1) | (1.6) | 68 (4.9) | 46 (3.6) | 10 (1.5) | 36 (5.8) | 16 (5.5) | 11 (4.7) | 5 (10.2) | 0.13 |
| Pristinamycin | 6 (0.2) | 5 (0.2) | 1 (0.1) | 5 (0.4) | 4 (0.6) | 1 (0.2) | 2 (0.7) | 0 | 2 (4.1) | 0.5 |
| C3G + Macrolide | 17 (0.6) | 0 | 17 (1.2) | 13 (1) | 0 | 13 (2.1) | 0 | 0 | 0 | 0.09 |
| Azithromycin | 28 (1) | 0 | 28 (2.1) | 0 | 0 | 0 | 5 (1.7) | 0 | 5 (10.2) | <0.001 |
| Amoxicillin-Clavulanate | 574 (18.9) | 0 | 574 (40.1) | 278 (21.5) | 0 | 278 (44.8) | 22 (7.5) | 12 (5.2) | 10 (16.3) | <0.001 |
| Others | 51 (1.7) | 4 (0.3) | 47 (7.4) | 35 (2.71) | 2 (0.3) | 33 (5.3) | 11 (3.8) | 0 | 11 (16.4) | 0.4 |
*p value of the comparison between the total antibiotic prescription in for the 3 centres participating to both periods (chi2)