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. 2016 Aug 12;4:83. doi: 10.1186/s40478-016-0348-x

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Racemization of Asp34 in MBP from controls (●) and multiple sclerosis (MS) patients suffering from SPMS (○) PPMS (◊) and RRMS (▽). Conversion of L-Asp34 was measured using the tryptic peptide HRDTGILDSIGR to (a) HR(D-isoAsp)TGILDSIGR and (b) HR(L-isoAsp)TGILDSIGR. Elevated racemization of Asp34 was detected in multiple sclerosis patients for both isoforms: HR(L-isoAsp)TGILDSIGR (p < 0.001, Mann–Whitney-U) and HR(D-isoAsp)TGILDSIGR (p = 0.002, Mann–Whitney-U). c An example of selected ion chromatographs from the tryptic digest of MBP from a control (66y) and a multiple sclerosis patient (48y). The percentage of modification was determined by the ion intensities of (HRDTGILDSIGR)/(HRDTGILDSIGR + HRDTGILDSIGR) × 100. Controls, n = 10; multiple sclerosis patients n = 8