Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Aug 12;4:83. doi: 10.1186/s40478-016-0348-x

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

PMC Copyright notice

Fig. 5 — Deamidation of Gln147 coupled with racemization of Asp145 in MBP from controls (●) and multiple sclerosis (MS) patients suffering from SPMS (○) PPMS (◊) and RRMS (▽). a Conversion of L-Asp145 to the D-isoAsp form in the deamidated peptide (GVDAEGTSK). Racemization of Asp145 to D-isoAsp GV(D-isoAsp)AEGTSK was significantly greater in multiple sclerosis patients (p < 0.001, Mann–Whitney-U). There was no significant difference for the other Asp isomers; GV(D-Asp)AEGTSK and GV(L-isoAsp)AEGTSK. The percentage of modification was calculated using the ion intensities of (GV(D-isoAsp)AEGTSK)/(GVDAEGTSK) × 100. b Selected ion chromatograph from the tryptic digest of MBP from a control (66y) and an multiple sclerosis patient (48y). Controls n = 10; multiple sclerosis patients n = 8