Table 1.
Experimental design for testing a human NmAb cocktail in the therapeutic mode.
| Group | Size | Animal ID | Virus exposure (day) | NmAb treatment (day) | NmAb dose (mg/kg) | CD8 depletion (day) | Necropsy (day) |
|---|---|---|---|---|---|---|---|
| 1 | 2 | 34342, 34337 | 0 | -- | -- | -- | 1 |
| 2a | 2 | 34263, 34290 | 0 | 1 | 10 | -- | 2 |
| 2b | 2 | 34365, 34345 | -- a | 1 | 10 | -- | 2 |
| 3 | 2 | 33172, 33186 | 0 | -- | -- | -- | 14 |
| 4 | 2 | 33379, 33400 | 0 | 1, 4, 7, 10 | 40 | -- | 14 |
| 5 | 6 | 33165, 33216, 33260, 33261, 33308, 33309 | 0 | 1, 4, 7, 10 | 40 | -- | 168 |
| 6 | 4 | 33494, 33505, 33536, 33537 | 0 | 1, 4, 7, 10 | 10 | 168–196 | 196 |
| 7b | 8 | 28792, 28785 29003, 29010 29012, 29077 29079, 29081 |
0 | -- | -- | -- | 168 |
a
Indicates none or not done.
b
published previously30