. Author manuscript; available in PMC: 2016 Sep 21.

Published in final edited form as: Nat Med. 2016 Mar 21;22(4):362–368. doi: 10.1038/nm.4063

Table 2.

Neutralizing activity in tissue homogenates of infant rhesus macaques co-localizes with virus

NmAb cocktail dose			10 mg/kg						No NmAb		40 mg/kg

Day of sample collection	1 ^a,^b				2 ^c				14 ^d,^e

Animal ID	34342	34337	34365	34345	34263		34290		33172	33186	33379	33400
	vRNA	vRNA	ID₅₀		ID₅₀	vRNA	ID₅₀	vRNA	vRNA	vRNA	ID₅₀	ID₅₀
Cerebellum									1,936.7	1,334.7
Buccal mucosa			<20	<20	<20		32				72	88
Pharyngeal mucosa			<20	<20	<20		<20					54
Mixed Mesenteric LN	1.3	0.2	44	56	66		32	0	417,832.3	671,839.9	36	175
Spleen	0	0	74	34	71		52	0	887,585.7	392,031.7	145	157
Iliosacral LN	0.7	65.1
Inguinal LN								0
Colon	0.2	0	72	34	96		289	0	1,410,029.7	105,623.6	33	245
Rectum			<20	28	58		71				<20	42
Repro Tract			71	82	79		386				69	110

SHIV day 0. No NmAb. Necropsy day 1. (34342, 34337). Quantified vDNA (Supplementary Table 2).

NmAbs day 0. No SHIV. Necropsy day 1. (34365, 34345)

Oral SHIV day 0 and s.c. NmAbs day 1. No vDNA (Supplementary Table 2). Necropsy day 2. (34263, 34290)

Oral SHIV day 0. No NmAb. Necropsy day 14. (33172, 33186)

Oral SHIV day 0 with s.c. NmAbs day 1, 4, 7 and 10. No vDNA (Supplementary Table 2). (33379, 33400)

ID₅₀ = Dilution of plasma that results in 50% neutralization of SHIV_SF162P3 in TZM-bl cells. SIVgag viral RNA (copies/1 × 10⁶ cell equivalents); coded samples; ultrasensitive nested QPCR and RT-PCR in 12 replicates Blank = No data