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Effects of an LD90 PDT dose using Photofrin. Fluorescence microscopy was used to assess photodamage to specific organelles 10 min after irradiation. (a, b) Lysotracker Green (LTG) fluorescence assessing the lysosomal pH gradient. (c, d) Rhodamine 123 (R123) reporting on the mitochondrial membrane potential (ΔΨm). (a, c) controls; (b, d) effects of photodamage
