Table 2.
Baseline and 1-year clinical data in svPPA and bvFTD groups at each field strength.
| svPPA |
bvFTD |
|||||||
|---|---|---|---|---|---|---|---|---|
| 1.5 T |
3 T |
1.5 T |
3 T |
|||||
| Measurea | Baseline (n, S.D.) |
Followup (n, S.D.) |
Baseline (n, S.D.) |
Followup (n, S.D.) |
Baseline (n, S.D.) |
Followup (n, S.D.) | Baseline (n, S.D.) |
Followup (n, S.D.) |
| General functioning | ||||||||
| MMSE | 22.42 (24; 7.98) |
20.16 (25; 7.88) |
25.06 (16; 5.12) |
23.11 (18; 5.99) |
22.57 (14; 9.1) |
21.08 (12; 8.71) |
24.52 (21; 4.07) |
20.22 (18; 7.54) |
| CDR-SB | 3.73 (24; 2.29) |
5.13 (23; 2.90) |
3.68 (19; 2.19) |
4.53 (20; 2.53) |
6.5 (14; 3.36) |
10.41 (11; 4.18) |
7.22 (23; 3.04) |
9.5 (22; 3.15) |
| Memory scores | ||||||||
| CVLT- immediate recall (Max = 36) |
16.0 (18; 6.65) |
13.17 (18; 6.91) |
18.87 (15; 5.51) |
16.2 (15; 5.38) |
20.5 (10; 6.82) |
20.2 (10; 9.92) |
22.0 (13; 6.1) |
18.62 (13; 6.49) |
| CVLT- long delay (Max = 9) |
2.83 (18; 2.28) |
1.67 (18; 2.47) |
3.4 (15; 2.17) |
1.87 (15; 2.2) |
4.6 (10; 2.41) |
4.4 (10; 3.66) |
5.38 (13; 1.5) |
4.08 (13; 2.4) |
| CVLT− Recognition Discrim. (d’′) |
1.58 (18; 1.15) |
1.57 (17; 0.83) |
1.84 (15; 1.06) |
1.41 (14; 1.03) |
2.43 (10; 0.73) |
2.41 (10; 1.0) |
2.05 (13; 1.18) |
1.56 (13; 1.15) |
| Benson recall (Max = 17) |
7.33 (18; 4.12) |
7.37 (16; 5.3) |
6.4 (15; 4.73) | 5.2 (10; 4.49) |
9.7 (10; 4.47) |
7.2 (10; 6.27) |
7.15 (13; 4.54) |
6.78 (9; 6.46) |
| Memory composite (z-score) |
−2.98 (18; 1.42) |
−3.46 (18; 1.56) |
−2.61 (15; 1.43) |
−3.52 (15; 1.51) |
−1.67 (10; 1.37) |
−2.01 (10; 2.18) |
−1.94 (13; 1.47) |
−2.86 (13; 1.68) |
| Language scores | ||||||||
| BNT (Max = 15) |
4.58 (19; 4.13) |
3.2 (20; 3.33) |
6.0 (16; 3.76) |
4.35 (17; 3.69) |
12.9 (10; 2.81) |
12.0 (10; 4.22) |
13.15 (13; 1.46) |
12.54 (13; 2.9) |
| Semantic fluency (Max in 1 min) |
7.17 (18; 4.3) |
4.72 (18; 3.27) |
7.81 (16; 4.23) |
6.56 (16; 5.62) |
12.5 (10; 6.54) |
10.7 (10; 7.18) |
11.31 (13; 3.07) |
7.69 (13; 4.94) |
| PPVT-R (Max = 16) |
9.73 (11; 4.5) |
6.4 (15; 4.37) |
9.94 (16; 4.02) |
7.92 (12; 4.03) |
14.11 (9; 2.32) |
14.0 (8; 2.0) |
14.54 (13; 1.71) |
13.0 (9; 2.74) |
| PPT (Max = 52) |
40.08 (13; 7.96) |
40.0 (13; 6.3) |
42.41 (17; 7.13) |
39.44 (9; 9.04) |
47.56 (9; 6.91) |
46.67 (6; 8.21) |
46.75 (12; 4.25) |
45.5 (6; 5.54) |
| WAIS-Information (Max = 28) |
8.71 (14; 5.66) |
7.29 (14; 5.85) |
10.63 (16; 5.37) |
9.6 (10; 6.9) |
16.56 (9; 7.54) |
16.71 (7; 8.06) |
17.08 (12; 5.71) |
16.8 (5; 3.42) |
| Semantic− Language composite (z-score) |
−5.8 (21; 2.59) |
−7.48 (21; 3.08) |
−5.17 (18; 2.72) |
−6.38 (18; 2.69) |
−1.69 (10; 2.22) |
−2.12 (10; 2.41) |
−1.68 (13; 1.27) |
−2.61 (13; 1.83) |
| Visuospatial scores | ||||||||
| WAIS-Block D (Max = 68) |
35.08 (12; 9.24) |
33.67 (15; 11.76) |
36.67 (12; 15.47) |
37.0 (9; 11.64) |
30.44 (9; 12.24) |
25.78 (8; 13.97) |
29.11 (9; 13.82) |
22.14 (7; 14.89) |
| Benson Copy (Max = 17) |
15.94 (16; 1.06) |
15.83 (18; 1.15) |
15.45 (11; 0.69) |
15.67 (12; 0.89) |
15.1 (10; 2.42) |
14.8 (9; 1.75) |
15.7 (10; 0.82) |
14.9 (10; 1.45) |
| VOSP (Max = 10) |
9.47 (15; 1.06) |
9.69 (16; 0.48) |
9.18 (11; 1.08) |
9.73 (11; 0.91) |
8.80 (10; 1.03) |
7.78 (8; 3.49) |
7.8 (10; 1.99) |
6.89 (9; 2.37) |
| Beery (Max = 16) |
15.07 (15; 1.16) |
13.44 (16; 2.53) |
13.75 (12; 2.01) |
12.73 (11; 4.29) |
13.33 (9; 2.24) |
11.63 (7; 3.38) |
14.33 (9; 1.58) |
11.57 (7; 3.6) |
| Visuospatial composite (z-score) |
0.2 (18; 0.69) |
−0.06 (18; 0.69) |
−0.17 (13; 0.75) |
−0.3 (13; 1.33) |
−0.5 (10; 1.12) |
−1.49 (9; 1.4) |
−0.53 (10; 0.87) |
−1.45 (10; 1.54) |
| Executive scores | ||||||||
| Design fluency (Max in 1 min) |
8.0 (13; 3.42) |
6.13 (15; 3.72) |
7.92 (13; 2.72) |
5.89 (9; 3.76) |
6.0 (9; 2.4) |
5.0 (7; 3.3) |
6.7 (10; 3.06) |
3.56 (9; 2.24) |
| Lexical fluency (Max in 1 min) |
8.13 (15; 4.0) |
5.13 (15; 3.7) |
7.0 (13; 2.24) |
7.0 (13; 2.92) |
9.91 (11; 5.59) |
8.91 (10; 5.89) |
9.3 (10; 3.5) |
5.4 (10; 4.45) |
| Trails set-shifting (Time to complete) |
64.33 (15; 37.55) |
69.87 (15; 38.42) |
49.75 (12; 29.62) |
55.15 (13; 31.87) |
73.3 (10; 42.69) |
84.18 (10; 44.91) |
63.4 (10; 41.36) |
86.7 (10; 43.58) |
| Stroop (Trials in 1 min) |
35.07 (14; 10.1) |
30.25 (12; 15.52) |
39.31 (13; 18.54) |
37.33 (6; 17.94) |
25.0 (11; 13.78) |
24.6 (9; 16.15) |
27.1 (10; 10.95) |
15.89 (9; 14.69) |
| Digits BW (Max Span) |
4.73 (15; 0.96) |
4.71 (14; 1.33) |
5.15 (13; 0.8) |
4.85 (13; 1.21) |
4.18 (11; 1.66) |
3.55 (10; 1.81) |
4.2 (10; 1.23) |
3.9 (10; 1.29) |
| Executive composite (z-score) |
−1.33 (15, 0.81) |
−1.79 (15, 1.1) |
−1.02 (13, 0.75) |
−1.48 (13, 0.95) |
−1.65 (11, 1.0) |
−2.41 (10, 1.53) |
−1.57 (10, 0.91) |
−2.47 (10, 1.21) |
a
See Methods (Section 2.2) for test names corresponding to abbreviations.