Table 1.

Cardiac biomarker details

	Limit of detection	Validated for rhesus macaques?
Cardiac troponin I	0.006–50 ng/mL	Yes (reference 4)
Creatine kinase-MB	10–2000 U/L	No
High-sensitivity C-reactive protein	0.2–160 mg/L	Yes (inhouse)
Lactate dehydrogenase	25–1200 U/L	Yes (inhouse)
Creatine phosphokinase	10–2000 U/L	Yes (inhouse)

All assays were performed on a model AU480 (Beckman Coulter) clinical analyzer except for cardiac troponin I (Advia Centuar TnI-Ultra, Siemens Healthcare Diagnostics). High-sensitivity C-reactive protein, lactate dehydrogenase, and creatine phosphokinase assays were validated in rhesus macaques in the clinical diagnostic laboratory of the California National Primate Research Center, and specific reference ranges were compiled based on results from a significant number of clinically healthy animals (n ≥ 40).