Table 3.
Unadjusted and Adjusted Associations Between Continuous Epicardial and Paracardial Fat Volume, Demographic/Clinical Risk Factors, and High-risk Plaque Features
| Dependent Variable: Any High-risk Plaque Feature Independent Variables |
Univariable Analysis | Multivariable Analysis Model: EAT (indexed volume) | Multivariable Analysis Model: PAT (indexed volume) | |||
|---|---|---|---|---|---|---|
| Unadjusted OR | p value | Adjusted OR | p value | Adjusted OR | p value | |
| Indexed Epicardial Fat Volume (continuous, cc/m2) | 1.02 (1.01–1.03) | <0.001 | 1.04 (1.00–1.08) | 0.040 | NA | NA |
| Squared Indexed Epicardial Fat Volume | 1.00 (1.00–1.00) | 0.001 | 1.00 (1.00–1.00) | 0.031 | NA | NA |
| Indexed Paracardial Fat Volume (continuous, cc/m2) | 1.02 (1.01–1.03) | <0.001 | NA | NA | 1.01 (0.99–1.04) | 0.215 |
| Squared Indexed Paracardial Fat Volume | 1.00 (1.00–1.00) | <0.001 | NA | NA | 1.00 (1.00–1.00) | 0.065 |
| Age (years) | 1.08 (1.05–1.10) | <0.001 | 1.03 (1.00–1.07) | 0.074 | 1.04 (1.00–1.08) | 0.030 |
| Female | 0.31 (0.21–0.46) | <0.001 | 0.36 (0.21–0.63) | 0.001 | 0.34 (0.19–0.63) | <0.001 |
| No. of cardiovascular risk factorsa | 1.48 (1.24–1.76) | <0.001 | 1.05 (0.84–1.32) | 0.655 | 1.09 (0.86–1.37) | 0.478 |
| Coronary artery calcium score (log) | 1.91 (1.71–2.13) | <0.001 | 1.69 (1.49–1.93)) | <0.001 | 1.71 (1.50–1.94) | <0.001 |
| Significant CAD (≥50% Stenosis) | 23.31 (8.17–66.51) | <0.001 | 5.66 (1.73–18.51) | 0.004 | 4.97 (1.53–16.20) | 0.008 |
The summary is based on all 467 observations; 95% Confidence Intervals in brackets
a
Risk factors include arterial hypertension, diabetes mellitus, dyslipidemia, former or current smoker, family history of CAD CAD = Coronary artery disease; OR = Odds Ratio, NA = not applicable