Table 4.
Unadjusted and Adjusted Associations Between Epicardial and Paracardial Fat Volume Thresholds, Demographic/Clinical Risk Factors, and High-risk Plaque Features
| Dependent Variable: Any High-risk Plaque Feature Independent Variables |
Univariable Analysis | Multivariable Analysisb Model: EAT (indexed volume) | Multivariable Analysisb Model: PAT (indexed volume) | |||
|---|---|---|---|---|---|---|
| Unadjusted OR | p value | Adjusted OR | p value | Adjusted OR | p value | |
| Indexed Epicardial Fat Volume (threshold ≥62.3 cc/m2) | 2.50 (1.69–3.72) | <0.001 | 1.83 (1.10–3.05) | 0.020 | NA | NA |
| Indexed Paracardial Fat Volume (threshold ≥33.6 cc/m2) | 4.12 (2.64–6.41) | <0.001 | NA | NA | 2.03 (1.15–3.59) | 0.015 |
| Age (years) | 1.08 (1.05–1.10) | <0.001 | 1.03 (1.00–1.07) | 0.087 | ||
| Female | 0.31 (0.21–0.46) | <0.001 | 0.42 (0.25–0.70) | 0.001 | 0.45 (0.25–0.80) | 0.007 |
| No. of cardiovascular risk factorsa | 1.48 (1.24–1.76) | <0.001 | ||||
| Coronary artery calcium score (log) | 1.91 (1.71–2.13) | <0.001 | 1.75 (1.56–1.97) | <0.001 | 1.69 (1.49–1.91) | <0.001 |
| Significant CAD (≥50% Stenosis) | 23.31 (8.17–66.51) | <0.001 | 5.19 (1.64–16.41) | 0.005 | 5.03 (1.54–16.47) | 0.008 |
The summary is based on all 467 observations; 95% Confidence Intervals in brackets
a
Risk factors include arterial hypertension, diabetes mellitus, dyslipidemia, former or current smoker, family history of CAD
b
Stepwise regression approach including number of cardiovascular risk factors, age, sex and CTA findings, excluding variables p>0.1
CAD = Coronary artery disease; OR = Odds Ratio; NA = not applicable