TABLE 5.
Odds Ratio (OR) and 95% Confidence Interval (CI) for Maternal Plasma Folate Receptor (FR) Autoantibodies Immunoglobulin G (IgG) and IgM Levels in Relation to Neural Tube Defects (NTDs), Stratified by Gestational Age, China, 2011–2013 (N = 327a)
| Autoantibody | Gestational age ≤20 weeks | Gestational age >20 weeks | ||||||
|---|---|---|---|---|---|---|---|---|
| Controls n |
NTDs | Controls n |
NTDs | |||||
| n | OR (95% CI) | aOR (95% CI)b | n | OR (95% CI) | aOR (95% CI)b | |||
| IgG | ||||||||
| Tertile 1 (<0.39) | 1 | 2 | Reference | Reference | 70 | 7 | Reference | Reference |
| Tertile 2 (0.39–1.07) | 1 | 3 | 1.50 (0.06–40.63) | 2.70 (0.08–95.00) | 71 | 22 | 3.10 (1.24–7.72) | 3.25 (1.21–8.71) |
| Tertile 3 (> 1.07) | 4 | 12 | 1.50 (0.11–21.31) | 2.01 (0.10–39.90) | 67 | 57 | 8.51 (3.62–19.97) | 8.47 (3.36–21.33) |
| P for trend | 0.794 | 0.751 | <0.001 | <0.001 | ||||
| IgM | ||||||||
| Tertile 1 (<1.47) | 2 | 1 | Reference | Reference | 68 | 14 | Reference | Reference |
| Tertile 2 (1.47–2.79) | 2 | 4 | 4.00 (0.21–75.66) | 8.78 (0.16–488.63) | 70 | 16 | 1.11 (0.50–2.45) | 1.09 (0.47–2.53) |
| Tertile 3 (>2.79) | 2 | 12 | 12.00 (0.71–203.13) | 18.98 (0.51–699.56) | 70 | 56 | 3.89 (1.98–7.62) | 4.50 (2.17–9.31) |
| P for trend | 0.078 | 0.109 | <0.001 | <0.001 | ||||
a
Twenty-three participants were excluded due to failure to obtain the maternal blood sample.
b
Adjusted for age, parity, periconceptual folate supplementation, and gestational age.
aOR, adjusted odds ratio.