Figure 7.

The effects of nimodipine, a blocker of L-type voltage-gated calcium channels, on synaptic transmission at ON-MC synapses. (A) Electrical and calcium signaling at ON-MC synapses before, during, and after application of nimodipine (10 μM) to the bath solution. (B) summary data (mean ± SEM, n = 4) obtained as illustrated in A. Note that nimodipine exhibited no significant effect on either the Ca²⁺ signal or the EPSPs. Ca²⁺ signals, and EPSPs were normalized to the responses obtained in control ACSF and expressed as the mean ± SEM. (C) Effect of nimodipine (10 μM) on the field EPSPs evoked by ON stimulation and recorded in glomeruli. (Inset) Field EPSPs before (dotted line) and during (solid line) application of nimodipine. Horizontal lines demark the amplitude of the field EPSP. (D) Summary data (mean ± SEM, n = 5) obtained as illustrated in C. NPD, nimodipine.