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. Author manuscript; available in PMC: 2017 Sep 1.
Published in final edited form as: Anal Bioanal Chem. 2016 Jul 1;408(22):6079–6091. doi: 10.1007/s00216-016-9716-4

Fig. 3. Coverage comparison of RP-C18, mixed-mode and HILIC methods.

Fig. 3

Numbers inside circles: Metabolites exclusively detected with each method. Center: compounds detected with both. Percentages relative to detectable compounds in library (714). a: Metabolites with good peakshapes. b: Well-retained compounds with good peakshapes and retention factors k ≥ 1. c: Overlapping selectivity ranges for zwitterionic HILIC methods (B vs. E), zwitterionic and neutral SPs (E and B vs. F), SPs with terminal amino groups (E vs. G), neutral HILIC (D vs. F) and for a mixed-mode column run in RP and HILIC modes (C vs. D).