Table 2. Race/ethnicity-stratified ABO association analysis results.
Analyses with log-transformed protein values of vWF, sE-selectin, sP-selectin, and sICAM-1, adjusted for age, sex, BMI, and genetic ancestry. Betas correspond to coefficient estimates from the regression analyses.
| vWF | |||||||||
|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||
| Allele (O ref.) |
African American n=175 |
Chinese Americana n=95 |
Non-Hispanic White n=440 |
Hispanic American n=218 |
|||||
|
| |||||||||
| Beta (SE) | p | Beta (SE) | p | Beta (SE) | p | Beta (SE) | p | ||
| A1 | 0.29 (0.06) | 1.9E-05 | 0.24 (0.06) | 2.5E-04 | 0.25 (0.03) | <1E-08 | 0.24 (0.04) | 1.1E-07 | |
| A2 | 0.22 (0.08) | 3.7E-03 | - | - | 0.04 (0.05) | 0.40 | 0.10 (0.08) | 0.24 | |
| B | 0.34 (0.05) | <1E-08 | 0.26 (0.06) | 8.1E-05 | 0.36 (0.04) | <1E-08 | 0.31 (0.07) | 2.4E-05 | |
|
| |||||||||
| sE-selectin | |||||||||
|
| |||||||||
| n=176 | n=95 | n=439 | n=219 | ||||||
|
| |||||||||
| Beta (SE) | p | Beta (SE) | p | Beta (SE) | p | Beta (SE) | p | ||
|
| |||||||||
| A1 | −0.35 (0.08) | 3.2E-05 | −0.49 (0.08) | 2.7E-08 | −0.51 (0.03) | <1E-08 | −0.41 (0.04) | <1E-08 | |
| A2 | −0.05 (0.09) | 0.63 | - | - | −0.15 (0.04) | 0.0011 | 0.26 (0.08) | 0.0021 | |
| B | −0.04 (0.07) | 0.51 | −0.01 (0.08) | 0.86 | −0.02 (0.04) | 0.70 | −0.06 (0.07) | 0.47 | |
|
| |||||||||
| sP-selectin | |||||||||
|
| |||||||||
| n=541 | n=620 | n=637 | n=608 | ||||||
|
| |||||||||
| Beta (SE) | p | Beta (SE) | p | Beta (SE) | p | Beta (SE) | p | ||
|
| |||||||||
| A1 | −0.11 (0.03) | 1.7E-04 | −0.20 (0.02) | <1E-08 | −0.18 (0.02) | <1E-08 | −0.17 (0.02) | <1E-08 | |
| A2 | 0.02 (0.04) | 0.62 | - | - | −0.03 (0.03) | 0.45 | −0.01 (0.04) | 0.90 | |
| B | 0.07 (0.03) | 0.011 | −0.01 (0.02) | 0.51 | −0.01 (0.03) | 0.88 | 0.13 (0.03) | 1.0E-04 | |
|
| |||||||||
| sICAM-1 | |||||||||
|
| |||||||||
| n=489 | n=581 | n=599 | n=573 | ||||||
|
| |||||||||
| Beta (SE) | p | Beta (SE) | p | Beta (SE) | p | Beta (SE) | p | ||
|
| |||||||||
| A1 | −0.05 (0.03) | 0.085 | −0.07 (0.02) | 0.0021 | −0.06 (0.02) | 0.0026 | −0.01 (0.03) | 0.59 | |
| A2 | 0.04 (0.05) | 0.44 | - | - | −0.03 (0.03) | 0.40 | −0.09 (0.05) | 0.085 | |
| B | 0.01 (0.03) | 0.78 | 0.01 (0.02) | 0.55 | −0.03 (0.03) | 0.37 | 0.06 (0.04) | 0.19 | |
SE: standard error.
a
A2 allele not present in Chinese Americans.