Table 3. Evaluation of potential race/ethnicity effect heterogeneity of ABO alleles on protein measurements.
vWF | |||||||||
---|---|---|---|---|---|---|---|---|---|
| |||||||||
Pooled Analysis | Meta-Analysis | ||||||||
| |||||||||
Allele | Beta (SE) | p | Interaction Test p |
Beta (SE) | p | Heterogeneity |
|||
Allele | Omnibus | Q | p | I2 | |||||
A1 | 0.25 (0.02) | <1E-08 | 0.99 | 0.83 | 0.25 (0.02) | <1E-08 | 0.40 | 0.94 | 2.0% |
A2 | 0.08 (0.04) | 0.020 | 0.27 | - | 0.10 (0.06) | 0.051 | 4.23 | 0.12 | 52.3% |
B | 0.33 (0.03) | <1E-08 | 0.64 | - | 0.32 (0.03) | <1E-08 | 1.60 | 0.66 | 13.3% |
| |||||||||
sE-selectin | |||||||||
| |||||||||
Pooled Analysis | Meta-Analysis | ||||||||
| |||||||||
Allele | Beta (SE) | p | Interaction Test p |
Beta (SE) | p | Heterogeneity |
|||
Allele | Omnibus | Q | p | I2 | |||||
| |||||||||
A1 | −0.47 (0.02) | <1E-08 | 0.20 | 0.0085 | −0.45 (0.04) | <1E-08 | 5.80 | 0.12 | 51.0 % |
A2 | −0.06 (0.04) | 0.13 | 7.5E-04 | - | 0.02 (0.12) | 0.88 | 18.33 | 1.0E-04 | 88.0% |
B | −0.04 (0.03) | 0.13 | 0.73 | - | −0.03 (0.03) | 0.33 | 0.35 | 0.95 | 0.9% |
| |||||||||
sP-selectin | |||||||||
| |||||||||
Pooled Analysis | Meta-Analysis | ||||||||
| |||||||||
Allele | Beta (SE) | p | Interaction Test p |
Beta (SE) | p | Heterogeneity |
|||
Allele | Omnibus | Q | p | I2 | |||||
| |||||||||
A1 | −0.17 (0.01) | <1E-08 | 0.16 | 0.012 | −0.17 (0.02) | <1E-08 | 6.53 | 0.088 | 62.4% |
A2 | −0.01 (0.02) | 0.67 | 0.58 | - | −0.00 (0.02) | 0.87 | 0.81 | 0.67 | 7.1% |
B | 0.03 (0.01) | 0.025 | 0.011 | - | 0.05 (0.03) | 0.19 | 11.22 | 7.0E-04 | 82.5% |
| |||||||||
sICAM-1 | |||||||||
| |||||||||
Pooled Analysis | Meta-Analysis | ||||||||
| |||||||||
Allele | Beta (SE) | p | Interaction Test p |
Beta (SE) | p | Heterogeneity |
|||
Allele | Omnibus | Q | p | I2 | |||||
| |||||||||
A1 | −0.05 (0.01) | 2.4E-05 | 0.40 | 0.41 | −0.05 (0.01) | 2.8E-04 | 2.61 | 0.46 | 27.0% |
A2 | −0.02 (0.02) | 0.29 | 0.21 | - | −0.02 (0.04) | 0.48 | 3.20 | 0.20 | 51.6% |
B | 0.01 (0.01) | 0.49 | 0.53 | - | 0.01 (0.02) | 0.63 | 2.68 | 0.44 | 32.7% |