FIG. 1.

Pathway analysis workflow. Pathways tested were retrieved from the Pathway Commons database. Genotyped (and imputed) SNPs were mapped to genes in the pathways, and six pathway analysis algorithms were used to test for association with ADHD. A random pathway permutation procedure was used to adjust pathway significance for pathway size. Finally, pathways were ranked based on the number of methods reporting significance and the median P-value across methods. [Color figure can be seen in the online version of this article, available at http://wileyonlinelibrary.com/journal/ajmgb]