Table 3.
Demographic and clinical variables of Healthy controls, Phenotype I and Phenotype II patients. Notably, this table was generated ‘post-hoc’ – after the unsupervised machine learning step.
| Healthy controls mean (SD) | Phenotype I mean (SD) | Phenotype II mean (SD) | p-value | |
|---|---|---|---|---|
| Age (years) | 32.93 (13.38) | 33.47 (13.05) | 34.34 (13.17) | 0.9042 |
| Female/total (N) | 22 (38) | 24 (38) | 17 (32) | 0.6963 |
| Education (Number of years) | 16.53 (3.68) | 13.19 (3.09) | 15.71 (2.37) | < 0.001 |
| BD subtype | 0.9468 | |||
| DSM IV bipolar disorder I (N) | - | 26 | 21 | |
| DSM IV bipolar disorder II (N) | - | 6 | 6 | |
| DSM IV bipolar disorder NOS (N) | - | 6 | 5 | |
| Current mood status | - | 0.6746 | ||
| Euthymic (N) | - | 7 | 12 | |
| Depressed (N) | - | 20 | 12 | |
| Manic (N) | - | 2 | 1 | |
| Hypomanic (N) | - | 3 | 0 | |
| Mixed (N) | - | 2 | 3 | |
| Undertermined (N) | - | 4 | 4 | |
| Age of manic (years) | - | 15.82 (14.12) | 10.70 (9.09) | 0.1209 |
| Age of depression (years) | - | 18.27 (13.28) | 16.53 (11.11) | 0.6049 |
| Comorbidities (total) (N) | - | 21 | 20 | 0.4236 |
| Current lithium (N) | - | 1 | 4 | 0.1026 |
| Current severity | - | 2.27 (1.43) | 3.64 (2.06) | 0.0096 |
| HAMD (total) | - | 14.06 (7.33) | 11.93 (8.94) | 0.3031 |
| MADRAS (total) | - | 18.76 (10.38) | 15.59 (12.32) | 0.2707 |
| YMRS (total) | - | 6.74 (5.56) | 4.43 (4.60) | 0.0757 |
BD- bipolar disorder, SD- standard deviation, HAMD- Hamilton rating scale for depression, MADRS- Montgomery-Asberg Depression Scale, YMRS- young mania rating scale.