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Morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G) are both morphine metabolites. In the stereoselective morphine activation, specific receptors of morphine bind with M6G. However, non-stereoselective morphine activation requires the participation of M3G, for TLR4 on glia cells. M3G competes with LPS for the same binding site on TLR4, which in turn results in the potentiation of the opioid analgesic effect.
