. Author manuscript; available in PMC: 2017 Jan 19.

Published in final edited form as: ChemMedChem. 2015 Jul 1;11(2):154–165. doi: 10.1002/cmdc.201500188

Table 3.

TLR4 antagonists and agonists

Mechanism	Antagonist/agonist	References
Block binding between MD2 and TLR4	MD2 I	^[12b]
	YH1/YH3	^[36]
	β-amino alcohol derivatives	^[37a]
Block binding between MD2 and LPS	Tricyclic anti-depressants	^[37b]
LPS sequestrants	Polymixin B	^{[18g, 40, 47]}
Block binding of CD-14	Haemin and three sugar-derived small molecules	^[54] ^[55]