Table 5.

Results from the SEAP Reporter Gene Activation Assay^*

Compound	R1†	R2†	Inhibition (%)
8	2-Cl	4-OEt#	52
9	H	H	1
10	2-Cl	4-Cl	99

^*The percent of inhibition was determined by measuring LPS-induced TLR4 activation in HEK293 cells, in the presence of 50 μM drug (compound) as compared to blank control.

^#Et = Ethyl group.

^†R¹ & R² = functional groups on the aromatic rings of T5342126-based inhibitors.