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. 2016 Mar 15;21:567–578. doi: 10.1007/s10741-016-9544-9

Table 1.

Analytical characteristics of commercial BNP assays as per the manufacturer (70)

Commercial diagnostic tests Capture antibody Detection antibody Standard material FDA cleared yes/no/claim
Abbott
Architect, AxSYM
iSTAT
NH2 terminus and part of the ring structure (Scios), murine monoclonal AB, aa 5–13 COOH terminus, murine monoclonal AB, aa 26–32 Synthetic BNP 32 Assist in diagnosis of HF
Assess severity of disease
Alerea
Triage BNP
NH2 terminus and part of the ring structure (Scios), murine monoclonal AB, aa 5–13 BNP (Biosite), murine omniclonal AB, epitope not characterized Recombinant BNP Aid in diagnosis and severity assessment of HF
Risk stratification of patients with ACS and HF
FDA cleared
Beckman Coultera
Access, Access 2, DxI
BNP (Biosite), murine omniclonal AB, epitope not characterized NH2 terminus and part of the ring structure (Scios), murine monoclonal AB, aa 5–13 Recombinant BNP Diagnosis HF
Assess severity HF
Risk ACS
Risk HF
Siemens (Bayer)
ACS 180, Advia Centaur, Advia Centaur CP
COOH terminus (BC-203) (Shionogi), murine monoclonal AB, aa 27–32 Ring structure (KY-hBNPII) (Shionogi), murine monoclonal AB Synthetic BNP Aid in diagnosis and severity assessment of HF
Predict survival and likelihood of future HF in ACS patients
Siemens (Dade Behring)
Dimension VISTA
Dimension ExL
Ring structure (KY-hBNPII) murine monoclonal AB, aa 14–21 COOH terminus (BC-203), murine monoclonal AB, aa 27–32 Synthetic BNP 32 Aid in diagnosis and severity assessment of HF
Predict survival and likelihood of future HF in ACS patients
Pending FDA clearance
Shionogi COOH terminus (BC-203), murine monoclonal AB, aa 27–32 Ring structure (KY-hBNPII), murine monoclonal AB Synthetic BNP Not FDA cleared
Tosoh
ST AIA-PACK BNP
COOH terminus (BC-203), murine monoclonal AB, aa 27–32 Ring structure (KY-hBNPII), murine monoclonal AB Synthetic BNP Not FDA cleared

CHF congestive heart failure, ACS acute coronary syndrome, aa amino acid, AB antibody

aBoth the Alere and Beckman systems use the same two antibodies, but due to their different assay formats, designation of the monoclonal and omniclonal antibodies as capture and detection antibody is not absolute