Table 1.
DSM-5 CUD | DSM-5 MSU | ||||
---|---|---|---|---|---|
Gene | # Tested markers (%rarea) | Qb | P-value | Q | P-value |
CNR1 | 5 (0%) | 306.68 | 0.2736 | 34.571 | 0.3241 |
FAAH | 6 (66.67%) | 5.728 | 0.0035c | 2.499 | 0.1066 |
MGLL | 6 (83.33%) | 0.989 | 0.6195 | 1.051 | 0.5675 |
DAGLA | 4 (75%) | 2.535 | 0.0898 | 2.666 | 0.0814 |
DAGLB | 9 (77.78%) | 1.236 | 0.6352 | 1.167 | 0.6526 |
The MAF cutoff for common vs rare variants is calculated in SKAT as follows: 1/ √[2 SampleSize]
The test statistic of SKAT
Survived Bonferroni correction for multiple testing at p < 0.004