TABLE 1.

Functions of IL-1α and IL-1β during C. albicans and A. fumigatus infection.

	IL-1α	IL-1β
	Recombinant IL-1α increases survival in a neutropenic mouse model of invasive candidiasis [31]	Recombinant IL-1β increases survival in a neutropenic mouse model of invasive candidiasis [31]
C. albicans	Endogenous IL-1α needed for optimal antifungal activity of neutrophils against pseudohyphae, and Th1 response [28]	Endogenous IL-1β needed for recruitment of neutrophils, superoxide generation, and Th1 response [28]
		NLRP3 and NLRC4-dependent IL-1β production [32–35]
	IL-1α needed for neutrophil recruitment [29]	IL-1β needed for optimal antifungal activity of macrophages [29]
A. fumigatus		NLRP3- and AIM2- dependent IL-1β production [47, 49, 50]
		NLRP3-dependent neutrophil recruitment [47, 49]