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Recently described regulatory components of STING-mediated activation of type I IFN.
Pink — SCAP-mediated recruitment of IRF3 to STING; blue — TRIM9s-facilitated interaction of TBK1 with GSK3β; green — inhibitory effect of PPM1A on phosphorylation of TBK1 and STING; gray — BTK1-induced activation of DDX41 and its recruitment to STING; brown — inhibitory effect of NLRX1 on interaction between TBK1 and STING
