Table 1.

Interference of viral proteins with components of STING signaling pathway.

Virus	Viral protein	Pathway inhibited	Ref.
KSHV	vIRF1	Blocks STING interaction with TBK1	[46]
Adenovirus	E1a	Blocks unknown NTD STING mediated signal	[48]
HSV1	VP24	Interacts with IRF3 and blocks phosphorylation of IRF3 by TBK1	[49]
IAV	HA2 fusion peptide	Inhibits STING dimerization in response to membrane fusion	[26••]
HTLV-1	Tax	Inhibits TBK1 phosphorylation of IRF3 by interactions with TBK1	[50]
HCV	NS4B	Inhibits STING accumulation by direct interaction with STING	[47]
KSHV	ORF52	Blocks cGAS binding of DNA	[45]
HBV	Pol	Blocks K63 ubiquitination of STING by binding STING	[44]
Coronavirus	PLP2-TM	Induces STING–Beclin1 interactions to degrade STING	[51]
SARS	PLpro-TM	Inhibits TRAF3/TBK1/STING interactions	[52]