Table 1.

Summary of genes down-regulated ≥ 2-fold 24 hours post treatment of FSH in GCs transduced with Ad-FOXO1(A3) versus Ad-E (Genes repressed by FOXO1 in the absence of FSH)

Gene	Common Name	Fold change (a/b)	FSH + Ad-E Unique reads	FSH + Ad-E RPXM (a)	FSH + Ad- FOXO1(A 3) Unique reads	FSH + Ad- FOXO1(A3) RPXM (b)
P2rx7	Purinergic receptor P2X, ligand gated ion channel,	−14.71	19	1.74	4	0.12
Nppc	Natriuretic peptide C	−10.55	41	25.2	7	2.39
Cyp19a1	Cytochrome P450, family 19, subfamily A, polypeptide 1	−6.37	278	27.7	58	4.35
Dhh	Desert Hedgehog	−5.64	62	8.62	18	1.53
Pappa	Pregnancy-associated plas- ma protein A, pappalysin 1	−4.95	174	7.79	66	1.57
Sfrp4	Secreted frizzled-related protein 4	−4.65	89	6.86	34	1.47
Lhcgr	Luteinizing hormone/ choriogonadotropin receptor	−3.92	419	50.96	139	13
Scarb1	Scavenger receptor class B, Member 1	−3.89	4486	573.11	1637	147.37
Sgk	Serum/glucocorticoid regulated kinase	−3.53	749	23.46	291	20.8
Crabp2_2	Cellular retinoic acid binding protein 2	−3.42	202	108.76	65	31.85
Mdm2	Mouse double minute 2 homolog	−3.28	37	20.39	16	16.54
Inha	Inhibin alpha	−3.25	14653	3720.95	6064	1146.18
Kcnk5	Potassium channel, two pore domain subfamily K, member 5	−2.97	22	2.09	16	0.7
Inhba	Inhibin, beta A	−2.92	2225	299.69	1034	102.6
Arf6	ADP-ribosylation factor 6	−2.71	234	74.18	115	27.38
Ihh	Indian hedgehog	−2.51	48	7.49	26	2.98
Cebpa	CCAAT/enhancer binding protein (C/EBP), alpha	−2.47	200	27.23	108	11.04
Jund	Jun D protooncogene	−2.39	551	119.25	310	49.98
Inhbb	Inhibin, beta B	−2.36	720	82.23	418	35.24
Wnt11	Wingless-type MMTV integra- tion site family, member 11	−2.33	176	19.07	109	8.18
Grem2	Gremlin 2, DAN family BMP antagonist	−2.23	767	65.62	493	29.48
Id2	Inhibitor of DNA Binding 2	−2.18	633	112.51	484	51.59
Ppp2r3b	Protein phosphatase 2, regulatory subunit B", Beta	−2.08	70	9.37	51	4.51
Fkbp5	FK506 binding protein 5	−2.07	726	71.94	480	34.77
Csdc2	Cold shock domain containing C2, RNA binding	−2.05	379	46.38	275	22.6