Table 3.
Results of the covariate-adjusted multivariate linear regression model of the Geriatric Depression Scale as a function of neuritic plaque score, clinical diagnosis at the last Alzheimer’s Disease Center visit prior to death, and their interaction
| β | 95% CI | p-value | ||
|---|---|---|---|---|
| Clinical diagnostic category (HC as reference) | MCI | −0.69 | (−1.73,0.35) | 0.19 |
| dAD | 0.80 | (−0.53,2.13) | 0.24 | |
| Neuritic plaque score (none or sparse as reference) | Moderate | 0.39 | (−0.72,1.5) | 0.49 |
| Frequent | −0.28 | (−1.82,1.27) | 0.72 | |
| Interaction: MCI and neuritic plaque score | Moderate | 0.52 | (−1.3,2.34) | 0.57 |
| Frequent | 1.74 | (−0.51,3.99) | 0.13 | |
| Interaction: dAD and neuritic plaque score | Moderate | −1.53 | (−3.37,0.32) | 0.10 |
| Frequent | −1.13 | (−3.22,0.96) | 0.29 | |
| Education (years) | −0.04 | (−0.07,0) | 0.03 | |
| History of transient ischemic attack | 1.68 | (0.83,2.53) | <0.01 | |
| Depression, in last 2 years | 2.12 | (1.32,2.93) | <0.01 | |
| Current benzodiazepine use | 1.93 | (0.86,3.01) | <0.01 | |
| Current sleep aid use | 0.97 | (−0.13,2.06) | 0.08 | |
| Current anti-depressant use | −0.81 | (−1.64,0.03) | 0.06 | |
| Total NPI-Q score | 0.12 | (0.02,0.23) | 0.02 | |
| Intercept | 2.26 | (1.44,3.07) | <0.01 |
CI, confidence interval; dAD, dementia because of possible or probable Alzheimer’s disease; HC, healthy control; MCI, mild cognitive impairment; NPI-Q, Neuropsychiatric Inventory Questionnaire.