Table 4.
Results of the covariate-adjusted multivariate linear regression model of the Geriatric Depression Scale as a function of Braak Stages of neurofibrillary pathology, clinical diagnosis at the last Alzheimer’s Disease Center visit prior to death, and their interaction
| β | 95% CI | p-value | ||
|---|---|---|---|---|
| Diagnostic Category (HC as reference) | MCI | 0.11 | (−3.43,3.64) | 0.95 |
| dAD | −0.88 | (−4.03,2.27) | 0.58 | |
| Braak Stages (0 as reference) | 1/2 | −1.15 | (−2.79,0.49) | 0.17 |
| 3/4 | −0.81 | (−2.54,0.92) | 0.36 | |
| 5/6 | −0.6 | (−3.49,2.28) | 0.68 | |
| Interaction: MCI and Braak Stages (0 as reference)a | 1/2 | −0.56 | (−4.41,3.29) | 0.78 |
| 3/4 | −0.52 | (−4.25,3.21) | 0.78 | |
| Interaction: dAD and Braak Stages (0 as reference)a | 1/2 | 2.61 | (−100,6.22) | 0.16 |
| 3/4 | 0.23 | (−3.11,3.57) | 0.89 | |
| Education (years) | −0.04 | (−0.07,0.00) | 0.03 | |
| History of transient ischemic attack | 1.72 | (0.85,2.59) | <0.01 | |
| Depression, in last 2 years | 2.11 | (1.30,2.93) | <0.01 | |
| Current benzodiazepine use | 1.75 | (0.67,2.83) | <0.01 | |
| Current sleep aid use | 0.89 | (−0.22,2.00) | 0.11 | |
| Current anti-depressant use | −0.59 | (−1.43,0.24) | 0.16 | |
| Total NPI-Q score | 0.12 | (0.02,0.23) | 0.02 | |
| Intercept | 3.21 | (1.58,4.83) | <0.01 |
a
Too few individuals with Braak = 5/6 to fit interaction term.
CI, confidence interval; dAD, dementia because of possible or probable Alzheimer’s disease; HC, healthy control; MCI, mild cognitive impairment; NPI-Q, Neuropsychiatric Inventory Questionnaire.