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. 2016 Jun 8;32:113–119. doi: 10.1016/j.mib.2016.05.015

Figure 2.

Figure 2

Evasion of DNA sensors by viruses. Viral DNA is sensed by cGAS in the cytoplasm and IFI16 in the nucleus. cGAS and IFI16 signal to a common adaptor protein, STING, which recruits TBK1 to activate IRF3, which induces expression of type I IFN and other antiviral genes. IFI16, cGAS, and STING have all been inhibited by viruses, as shown here. Abbreviations: adenovirus (AdV), herpes simplex virus-1 (HSV-1), human immunodeficiency virus (HIV), human papillomavirus 18 (HPV18), and Kaposi's sarcoma associated herpes virus (KSHV).