Table 2.

Pharmacokinetic (PK) Parameter Summary for Zolpidem, ZPCA, and ZCA in each Group.

Parameter	HL	Tmax	Cmax	SE_Cmax	AUCall	SE_AUCall
Units	h	h	ng/mL	ng/mL	h∗ng/mL	h∗ng/mL
Zolpidem
Males	3.26	1	68.1	15.61	231.82	25.15
Males+disulfiram	2.89	0.083	127.5	9.5	141.69	12.94
Females+disulfiram	2.76	0.083	145	34	302.8	23.97
Females	8.39	1	112.35	17.65	537.77	50.36
Castrated Males	5.96	0.25	109.07	20.44	339.72	52.6
Zolpidem Phenyl 4-Carboxylic Acid
Males	3.17	1	101.7	44.18	257.38	37.28
Males+disulfiram	3.54	0.083	123	5	278.2	20.94
Females+disulfiram	2.62	0.25	162.63	40.22	324.83	25.87
Females	4.22	0.5	88.25	32.75	352.1	47.29
Castrated males	6.16	1	105.77	45.07	316.84	55.49
Zolpidem 6-Carboxylic Acid
Males	6.43	1	2.13	0.97	9.17	1.12
Males+disulfiram	9.2	0.083	2.52	0.455	8.69	0.062
Females+disulfiram	4.12	1	3.64	0.66	13.48	0.84
Females	6.38	3	1.74	0.164	10.31	0.591
Castrated males	6.27	2	1.65	0.176	6.92	0.432