Table 5.

Risk of Acute Myeloid Leukemia Associated With Paternal Ever-Smoking, by Selected Characteristics, Childhood Leukemia International Consortium, 1974–2012

Variable	Total Controls, no.	Total Cases, no.	Exposed, %		ORa	95% CI	P Value for Interactionb
			Controls	Cases
Child's ethnicity							0.08
Non-Hispanic white	3,951	307	54	58	1.10	0.87, 1.41
Hispanic	506	61	42	52	1.45	0.84, 2.50
Non-Hispanic other	475	47	47	64	1.81	0.94, 3.49
Highest parental education							0.26
None/primary	815	116	66	78	1.71	0.87, 3.39
Secondary	2,242	215	58	60	1.09	0.79, 1.50
Tertiary	2,487	197	44	50	1.25	0.92, 1.70
Child's birth weight, g							0.96
Low birth weight (<2,500)	479	41	56	71	1.39	0.58, 3.32
Normal birth weight (2,500–4,000)	4,482	426	53	61	1.21	0.96, 1.53
High birth weight (>4,000)	599	64	49	55	1.32	0.76, 2.29
Child's age, years							0.74
Age <1	247	56	52	50	1.04	0.55, 1.96
Age 1–4	2,574	187	49	58	1.36	0.96, 1.94
Age 5–9	1,583	141	55	66	1.35	0.86, 2.12
Age 10–14	1,156	147	58	63	1.11	0.74, 1.65

Abbreviations: CI, confidence interval; OR, odds ratio.

^a Odds ratios were adjusted for age, sex, ethnicity, highest parental education level, and study center, except when it was the variable of interest.

^b P value for interaction was derived from the −2 log likelihood estimate from multivariate analyses.