Fig. 7.
Impact of probe selection on [11C]WAY100635 (A), [11C]Ro15-4513 (B) and [11C]LY2795050 (C) analysis. Reference VND estimates as obtained from blocking studies (red bars) are compared with those obtained from genomic plot applications (blue bars). For each tracer all the probes available from the Allen Human Brain database were tested. Dark blue bars refer to VND estimates as obtained from the probes selected a priori from the database. Light blue bars refer to VND estimates derived by the probes discarded from the initial selection. For each probe the VND standard error and the correlation with PET tracer uptake are also reported (squared Pearson's correlation coefficient, R2). Probes are sorted in descending order based on their correlation values with PET.